BREAST CANCER

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+Upgrade Rates of High-risk Breast Lesions Diagnosed on Core Needle Biopsy: A Single-institution Experience and Literature Review
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This article is more recent, with many more high risk lesions on core needle biopsy with literature review.


Upgrade Rates of High-risk Breast Lesions Diagnosed on Core Needle Biopsy: A Single-institution Experience and Literature Review

Mooney KL, Basset LW, Apple SK, et al.

This article is more recent, with many more high risk lesions on core needle biopsy with literature review.
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+The Effect of 96-Hour Formalin Fixation on the Immunohistochemical Evaluation of Estrogen Receptor, Progesterone Receptor, and HER2 Expression in Invasive Breast Carcinoma
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This article examines the impact of 96-hour formalin fixation on ER/PR and HER2 immunohistochemical results from core biopsy specimens.


The Effect of 96-Hour Formalin Fixation on the Immunohistochemical Evaluation of Estrogen Receptor, Progesterone Receptor, and HER2 Expression in Invasive Breast Carcinoma

Isil Z. Yildiz-Aktas, MD et al.

This article examines the impact of 96-hour formalin fixation on ER/PR and HER2 immunohistochemical results from core biopsy specimens.

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+The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012 Aug;25(8):1098-105. doi: 10.1038/modpathol.2012.59. Epub 2012 Mar 30. PubMed PMID: 22460807.
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Breast resection specimens were subjected to variable cold ischemic time periods (0.5, 1, 2, 3, 4, 24, and 48 h) within the refrigerator and at room temperature.


The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012 Aug;25(8):1098-105. doi: 10.1038/modpathol.2012.59. Epub 2012 Mar 30. PubMed PMID: 22460807.

Yildiz-Aktas IZ, Dabbs DJ, Bhargava R. l

Breast resection specimens were subjected to variable cold ischemic time periods (0.5, 1, 2, 3, 4, 24, and 48 h) within the refrigerator and at room temperature. The study included 25 tumors, all of which had refrigerated samples. Non-refrigerated samples (samples at room temperature) were present on 23 cases. Hormone receptors were semi-quantitatively scored using the H-score method. Human epidermal growth factor receptor 2 gene ERBB2 (HER2) was scored using the ASCO/CAP guidelines. The results were compared with the core biopsy scores, which have negligible cold ischemic time period before fixation.
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+Breast Cancer Predictive Factor Testing: The Challenges and Importance of Standardizing Tissue Handling
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This article discusses the current standards for collection and preservation of clinical samples that have been in place for decades and have focused on tissue preservation for morphologic examination, with little if any attention paid to preserving the quality of macromolecules that may be in the tissue.


Breast Cancer Predictive Factor Testing: The Challenges and Importance of Standardizing Tissue Handling

David G. Hicks, LeeAnn Kushner, Kristin McCarthy

This article discusses the current standards for collection and preservation of clinical samples that have been in place for decades and have focused on tissue preservation for morphologic examination, with little if any attention paid to preserving the quality of macromolecules that may be in the tissue. Because of the importance of these markers for determining the most appropriate treatments available for each patient, there is a need for standardizing pre-analytic variables, with the goal of developing standardized methods of tissue procurement and processing, and documenting how these variables affect the quality of tissue for biomarker testing and molecular analysis.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: IHC to Diagnose ADH
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This short course will go over the diagnosis of ADH using CK5, ADH and ER.


Diagnostic Use of Immunohistochemistry in Breast Pathology: IHC to Diagnose ADH

Rohit Bhargava, M.D.

This short course will go over the diagnosis of ADH using CK5, ADH and ER.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Papillary Lesions
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This course will discuss papillary lesions which include: intraductal papilloma, papilloma with ADH, papilloma with DCIS, papillary DCIS, encapsulated (intracystic/encysted) papillary carcinoma, solid papillary carcinoma and invasive papillary carcinoma.


Diagnostic Use of Immunohistochemistry in Breast Pathology: Papillary Lesions

Rohit Bhargava, M.D.

This course will discuss papillary lesions which include: intraductal papilloma, papilloma with ADH, papilloma with DCIS, papillary DCIS, encapsulated (intracystic/encysted) papillary carcinoma, solid papillary carcinoma and invasive papillary carcinoma.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Spindle Cell Lesions
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This mini course will discuss how metaplstic carcinomas are heterogenerous and describe how to diagnose problematic cases which show predominant spindle cell morphology.


Diagnostic Use of Immunohistochemistry in Breast Pathology: Spindle Cell Lesions

Rohit Bhargava, M.D.

This mini course will discuss how metaplstic carcinomas are heterogenerous and describe how to diagnose problematic cases which show predominant spindle cell morphology.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Lymphatic Space Invasion
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This course will explain the use of D2-40 as a selective lymphatic endothelial marker and how it can be helpful in identifying lymphatic space invasion and identifying lymphatic tumor emboli in cases of inflammatory carcinoma.


Diagnostic Use of Immunohistochemistry in Breast Pathology: Lymphatic Space Invasion

Rohit Bhargava, M.D.

This course will explain the use of D2-40 as a selective lymphatic endothelial marker and how it can be helpful in identifying lymphatic space invasion and identifying lymphatic tumor emboli in cases of inflammatory carcinoma.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Assessment of Invasion
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This mini course will diagnose invasive carcinoma prior to a definitive excision procedure, describe how immunohistochemical (IHC) stains supplement the morphologic diagnosis, and list the markers available for the assessment of invasion.


Diagnostic Use of Immunohistochemistry in Breast Pathology: Assessment of Invasion

Rohit Bhargava, M.D.

Course Description: This mini course will diagnose invasive carcinoma prior to a definitive excision procedure, describe how immunohistochemical (IHC) stains supplement the morphologic diagnosis, and list the markers available for the assessment of invasion.
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+Diagnostic Use of Immunohistochemistry in Breast Pathology: Invasive Ductal vs. Invasive Lobular
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This short course will explain the differences between invasive ductal vs. invasive lobular.


Diagnostic Use of Immunohistochemistry in Breast Pathology: Invasive Ductal vs. Invasive Lobular

Rohit Bhargava, M.D.

This short course will explain the differences between invasive ductal vs. invasive lobular. It will also explain when to use E-cadherin for tumors with ambiguous morphology.
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+The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer
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This article reviews pre-analytic literature to identify whether minimum formalin fixation time may be reduced for reliable ER/PR and HER2 IHC determination.


The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer

Shona Kalkman, MD et al.

This article reviews pre-analytic literature to identify whether minimum formalin fixation time may be reduced for reliable ER/PR and HER2 IHC determination.
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