LUNG CANCER

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Interpretation & Reporting

IHC and special stains

+A Sensitive ALK Immunohistochemistry Companion Diagnostic Test Identifies Patients Eligible for Treatment with Crizotinib
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A study on the automated ALK (D5F3) companion diagnostic IHC assay available from Ventana and its correlation with outcomes for patients with ALK-rearranged lung cancers


A Sensitive ALK Immunohistochemistry Companion Diagnostic Test Identifies Patients Eligible for Treatment with Crizotinib

Thorne-Nuzzo T, et al.

A study on the automated ALK (D5F3) companion diagnostic IHC assay available from Ventana and its correlation with outcomes for patients with ALK-rearranged lung cancers
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+GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung.
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The authors suggest using GATA3 immunostain as a marker to distinguish between sarcomatoid lung carcinomas and sarcomatoid mesotheliomas.


GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung.

Berg, Kyra B. MD; Churg, Andrew MD

The authors suggest using GATA3 immunostain as a marker to distinguish between sarcomatoid lung carcinomas and sarcomatoid mesotheliomas. This stain shows a diffuse positivity with the latter but is mostly negative in sarcomatoid lung carcinomas.
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+EBUS-TBNA as a Promising Method for the Evaluation of Tumor PD-L1 Expression in Lung Cancer
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This article reviews the validity of PD-L1 expression testing in EBUS obtained cytology samples using the EPR116 Abcam antibody.


EBUS-TBNA as a Promising Method for the Evaluation of Tumor PD-L1 Expression in Lung Cancer

Sakakibara R, Inamura K, Tambo Y, et al.

This article reviews the validity of PD-L1 expression testing in EBUS obtained cytology samples using the EPR116 Abcam antibody. The authors found superior yields with EBUS vs transbronchial biopsies and good concordnace between EBUS specimen and primary tumor for PD-L1 expression.
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+Improving Selection Criteria for ALK Inhibitor Therapy in Non–Small Cell Lung Cancer: A Pooled-Data Analysis on Diagnostic Operating Characteristics of Immunohistochemistry
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This study evaluates the diagnostic role of ALK immunohistochemistry (IHC) in identification of ALK rearrangement compared to FISH.


Improving Selection Criteria for ALK Inhibitor Therapy in Non–Small Cell Lung Cancer: A Pooled-Data Analysis on Diagnostic Operating Characteristics of Immunohistochemistry

Jiang, Long MD, PhD; Yang, Haihong MD, PhD; He, Ping MD, PhD, et al.

This study evaluates the diagnostic role of ALK immunohistochemistry (IHC) in identification of ALK rearrangement compared to FISH. Authors conclude that IHC scores of 0 and 3+ were nearly 100% concordant with FISH-negative and FISH-positive status, respectively. However, IHC scores 1+ and 2+ might require further confirmatory testing by FISH assay. IHC assay using D5F3 and 5A4 antibodies reliably detected NSCLC with ALK rearrangement and may be useful as a screening method to identify these tumors.
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+The Lung-Restricted Marker Napsin A Is Highly Expressed in Clear Cell Carcinomas of the Ovary
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This study looks at expression of Napsin A in ovarian tumors and finds high expression, 100%, in ovarian clear cell carcinoma.


The Lung-Restricted Marker Napsin A Is Highly Expressed in Clear Cell Carcinomas of the Ovary

Patricia L. Kandalaft, MD; Allen M. Gown, MD; Christina Isacson, MD

This study looks at expression of Napsin A in ovarian tumors and finds high expression, 100%, in ovarian clear cell carcinoma. Manuscript primarily focused on differentiating ovarian tumors and only one paragraph dedicated to distinguishing lung CA with clear cell features from metastatic ovarian CC Ca.
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+Usefulness of Cdx2 in Separating Mucinous Bronchioloalveolar Adenocarcinoma of the Lung From Metastatic Mucinous Colorectal Adenocarcinoma
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Study found CDX2 is a specific and sensitive marker for distinguishing metastatic colorectal carcinoma from primary mucinous lung adenocarcinoma.


Usefulness of Cdx2 in Separating Mucinous Bronchioloalveolar Adenocarcinoma of the Lung From Metastatic Mucinous Colorectal Adenocarcinoma

Reda S. Saad, MD, PhD; Patrick Cho, MD; Jan F. Silverman, MD; Yulin Liu, MD, PhD

Study found CDX2 is a specific and sensitive marker for distinguishing metastatic colorectal carcinoma from primary mucinous lung adenocarcinoma.
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+Primary Oncocytic Adenocarcinomas of the Lung: A Clinicopathologic, Immunohistochemical, and Molecular Biologic Analysis of 16 Cases
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Paper describes interetsting and rare variant of oncocytic lung adenocarcinoma. Useful paper with strong scientific merit.


Primary Oncocytic Adenocarcinomas of the Lung: A Clinicopathologic, Immunohistochemical, and Molecular Biologic Analysis of 16 Cases

Luisa M. Solis, MD; M. Gabriela Raso, MD; Neda Kalhor, MD; et al.

Paper describes interetsting and rare variant of oncocytic lung adenocarcinoma. Useful paper with strong scientific merit.
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FISH and molecular testing

+Template for Reporting Results of Biomarker Testing of Specimens From Patients With Non–Small Cell Carcinoma of the Lung
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The College of American Pathologists suggested templates when reporting results of biomarker testing to assist pathologists in providing clinically useful and relevant information


Template for Reporting Results of Biomarker Testing of Specimens From Patients With Non–Small Cell Carcinoma of the Lung

Philip T. Cagle, MD; Lynette M. Sholl, MD; Neal I. Lindeman, MD, et al.

The College of American Pathologists suggested templates when reporting results of biomarker testing to assist pathologists in providing clinically useful and relevant information
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+Template for reporting results of biomarker testing of specimens from patients with non-small cell carcinoma of the lung
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Self-explanatory. A useful template for reporting biomarkers for lung cancer


Template for reporting results of biomarker testing of specimens from patients with non-small cell carcinoma of the lung

Cagle PT, et al.

Self-explanatory. A useful template for reporting biomarkers for lung cancer
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Other considerations

+Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model
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A risk assessment model for determining the likelihood for malignant behavior in solitary fibrous tumors, including those arising in the lung


Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model

Demicco EG, et al.

A risk assessment model for determining the likelihood for malignant behavior in solitary fibrous tumors, including those arising in the lung
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+The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification
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A nice and concise summary of the changes and additions made in the new 2015 WHO Classification of Lung Tumors


The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification

Travis WD, et al.

A nice and concise summary of the changes and additions made in the new 2015 WHO Classification of Lung Tumors
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+Lung Carcinoma Staging Update
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This short article is a brief review of the 8th edition staging system for lung cancer. The article primarily discusses the main changes to the T, N and M categories


Lung Carcinoma Staging Update

Dacic, S

This short article is a brief review of the 8th edition staging system for lung cancer. The article primarily discusses the main changes to the T, N and M categories
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+Challenges of Frozen Section in Thoracic Pathology: Lepidic Lesions, Limited Resections, and Margins
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This article discusses the pitfalls and challenges in frozen section evaluation. Common and rare scenarios are reviewed.


Challenges of Frozen Section in Thoracic Pathology: Lepidic Lesions, Limited Resections, and Margins

Borczuk AC.

This article discusses the pitfalls and challenges in frozen section evaluation. Common and rare scenarios are reviewed.
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+Evaluation of the 7th and 8th editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort. Oncotarget. 2017 May 24.
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The authors discuss modifications to the most recent staging system for lung cancer, highlighting improvements and contrasting with the prior staging system.


Evaluation of the 7th and 8th editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort. Oncotarget. 2017 May 24.

Yang L, Wang S, Zhou Y, et al.

The authors discuss modifications to the most recent staging system for lung cancer, highlighting improvements and contrasting with the prior staging system.
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+Semiquantitative Assessment of Tumor Spread through Air Spaces (STAS) in Early-Stage Lung Adenocarcinomas
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Authors performed a semiquantitative assessmentof STAS in surgically removed small (≤2 cm) stage I lung adenocarcinomas.


Semiquantitative Assessment of Tumor Spread through Air Spaces (STAS) in Early-Stage Lung Adenocarcinomas

Hironori U., Takeshi F., Sakashi F., et al.

Authors performed a semiquantitative assessmentof STAS in surgically removed small (≤2 cm) stage I lung adenocarcinomas. STAS was associated with aggressive behavior.
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+Papillary Lung Carcinoma with Prominent "Morular" Component
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Older study that reports the unusual finding of spindle cell morules in cases of papillary adenocarcinoma.


Papillary Lung Carcinoma with Prominent "Morular" Component

Cesar A. Moran, MD; Jaishree Jagirdar, MD, and Saul Suster, MD

Older study that reports the unusual finding of spindle cell morules in cases of papillary adenocarcinoma.
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+Primary Sclerosing Neuroendocrine Carcinomas of the Lung: A Clinicopathologic and Immunohistochemical Study of 10 Cases
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This study looks at sclerotic variant carcioind tumor. Useful review of unusual variant of common tumor.


Primary Sclerosing Neuroendocrine Carcinomas of the Lung: A Clinicopathologic and Immunohistochemical Study of 10 Cases

Neda Kalhor, MD; Saul Suster, MD; Cesar A. Moran, MD

This study looks at sclerotic variant carcioind tumor. Useful review of unusual variant of common tumor.
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+Neuroendocrine Carcinomas of the Lung
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Good review of neuroendocrine tumors from 2009.


Neuroendocrine Carcinomas of the Lung

Cesar A. Moran, MD; Saul Suster, MD; Domenico Coppola, MD; Mark R. Wick, MD

Good review of neuroendocrine tumors from 2010. 
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