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Tumor Acquisition & Adequacy

+Molecular Pathology of Non-Small Cell Lung Cancer: A Practical Guide
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Review article describing molecular testing of NSCLC and issues related to specimen handling and test selection


Molecular Pathology of Non-Small Cell Lung Cancer: A Practical Guide

Aisner D and Marshall C.

Review article describing molecular testing of NSCLC and issues related to specimen handling and test selection
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+NSCLC Subtype Prediction Using Cytologic Fluid Specimens From Needle Aspiration Biopsies
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A study investigating the utility of cytologic fluid specimens for detection of antigens to enable lung tumor subtyping


NSCLC Subtype Prediction Using Cytologic Fluid Specimens From Needle Aspiration Biopsies

Cho A, Hur J, Jin Hong Y, et al.

A study investigating the utility of cytologic fluid specimens for detection of antigens to enable lung tumor subtyping
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+A Quick Look at the Current Landscape of Molecular Testing in Lung Cancer – Case 1
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This mini course discusses selecting appropriate tissue acceptable for molecular testing, different types of EGFR mutations in lung adenocarcinoma, and testing options for EGFR testing.


A Quick Look at the Current Landscape of Molecular Testing in Lung Cancer – Case 1

Anna P. Matynia, M.D.

Course Description: This mini course discusses selecting appropriate tissue acceptable for molecular testing, different types of EGFR mutations in lung adenocarcinoma, and testing options for EGFR testing.
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+Efficacy and Safety of Cryobiopsy Versus Forceps Biopsy for Interstitial Lung Diseases and Lung Tumours: A systematic Review and Meta-Analysis 
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This is a meta-analysis of cryobiopsy studies looking at efficacy and complications of endobronchial cryobiopsies. The analysis found significantly better diagnostic yield with cryobiopsies but 1 of 3 studies found significantly more bleeding with this procedure.


Efficacy and Safety of Cryobiopsy Versus Forceps Biopsy for Interstitial Lung Diseases and Lung Tumours: A systematic Review and Meta-Analysis

Ganganah O, Guo SL, Chiniah M, et al.

This is a meta-analysis of cryobiopsy studies looking at efficacy and complications of endobronchial cryobiopsies. The analysis found significantly better diagnostic yield with cryobiopsies but 1 of 3 studies found significantly more bleeding with this procedure.
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+Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens 
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The authors compare the results of liquid biopsy with routine tissue molecular assays in a large cohotr of patients. They show that comprehensive liquid biopsy offers accurate and reliable detection of clinically relevant driver alterations in plasma of patients with cancer.


Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens

Müller J, Falk M, Talwar J, et al.

The authors compare the results of liquid biopsy with routine tissue molecular assays in a large cohotr of patients. They show that comprehensive liquid biopsy offers accurate and reliable detection of clinically relevant driver alterations in plasma of patients with cancer.
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+The Emerging Roles of NGS-based Liquid Biopsy in Non-Small Cell Lung Cancer 
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This review summarized the potential applications of NGS-based liquid biopsy in the diagnosis and treatment of NSCLC including identifying actionable genomic alterations, tracking spatiotemporal tumor evolution, dynamically monitoring response and resistance to targeted therapies, and diagnostic value in early-stage NSCLC, and discussed emerging challenges to overcome in order to facilitate clinical translation in future.


The Emerging Roles of NGS-based Liquid Biopsy in Non-Small Cell Lung Cancer

Zhang Y, Zhou Q, Wu Y, et al.

This review summarized the potential applications of NGS-based liquid biopsy in the diagnosis and treatment of NSCLC including identifying actionable genomic alterations, tracking spatiotemporal tumor evolution, dynamically monitoring response and resistance to targeted therapies, and diagnostic value in early-stage NSCLC, and discussed emerging challenges to overcome in order to facilitate clinical translation in future.
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+Fine-needle Aspiration Cytologic Diagnosis of Lymphoepithelioma-like Carcinoma of the Lung: Report of Two Cases With Immunohistochemical Study
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Older paper on rare tumor. Black and white images and lack of modern techniques (e.g. no EBV staining).


Fine-needle Aspiration Cytologic Diagnosis of Lymphoepithelioma-like Carcinoma of the Lung: Report of Two Cases With Immunohistochemical Study

Louis T.C. Chow, MRCPAth, FRW.H. Chow, MRCP, FICA Wilson M.S. Tsui, MRCPath, et al.

Older paper on rare tumor. Black and white images and lack of modern techniques (e.g. no EBV staining).
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+The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.
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This study examined the association of extent of lung resection, pathologic nodal evaluation, and survival for patients with clinical stage I (cT1-2N0M0) adenocarcinoma with lepidic histologic features in the National Cancer Data Base.


The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.

Cox, Yang, Speicher, et al.

This study examined the association of extent of lung resection, pathologic nodal evaluation, and survival for patients with clinical stage I (cT1-2N0M0) adenocarcinoma with lepidic histologic features in the National Cancer Data Base.
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+Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non–Small Cell Lung Cancer
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The feasibility of plasma testing for detecting EGFR mutations in advanced NSCLC is discussed.


Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non–Small Cell Lung Cancer

Jenkins, Yang, Ramalingam, et al.

The feasibility of plasma testing for detecting EGFR mutations in advanced NSCLC is discussed.
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+Management of the Solitary Pulmonary Nodule
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This article discusses the multidisciplinary process of the work up for lung nodules. It informs pathologists of the clinical management in these patients.


Management of the Solitary Pulmonary Nodule

Chan EY, Gaur P, Ge Y, et al.

This article discusses the multidisciplinary process of the work up for lung nodules. It informs pathologists of the clinical management in these patients.
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+Molecular biomarkers for lung adenocarcinoma
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A nice review of the current state of molecular testing in lung adenocarcinoma. Includes a useful discussion on different methods of sampling and issues relating to adequacy.


Molecular biomarkers for lung adenocarcinoma

Calvayrac O, et al.

A nice review of the current state of molecular testing in lung adenocarcinoma. Includes a useful discussion on different methods of sampling and issues relating to adequacy.
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+Test Feasibility of Next-Generation Sequencing Assays in Clinical Mutation Detection of Small Biopsy and Fine Needle Aspiration Specimens
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A quality assessment study of mutation detection in FFPE neoplastic tissues. Factors important to optimal tissue processing is discussed.


Test Feasibility of Next-Generation Sequencing Assays in Clinical Mutation Detection of Small Biopsy and Fine Needle Aspiration Specimens

Gang Zheng, MD, PhD; Harrison Tsai, MD, Li-Hui Tseng, MD, PhD, et al.

A quality assessment study of mutation detection in FFPE neoplastic tissues. Factors important to optimal tissue processing is discussed.
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+Rapid On-Site Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspirations for the Diagnosis of Lung Cancer: A Perspective From Members of the PulmonaryPathology Society
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In this article, the benefits of rapid on-site evaluation (ROSE) of transbronchial needle aspirations are reviewed.


Rapid On-Site Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspirations for the Diagnosis of Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society

Jain D, Allen TC, Aisner DL, et al.

In this article, the benefits of rapid on-site evaluation (ROSE) of transbronchial needle aspirations are reviewed.
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